Company Overview

Ansella Therapeutics is specialty pharmaceutical company that leverages biomimetic sciences to develop novel therapeutics that improve healthcare outcomes. The company’s initial focus is on women’s health, specifically in the development of novel vaginal formulations.

Biomimetics is an interdisciplinary field in which principles from engineering, chemistry and biology are applied to the synthesis of materials, or synthetic systems that have functions that mimic biological processes. Biomaterials are any natural or synthetic material that interacts with any part of a biological system. Biomimetic designs can be used in regenerative medicine, tissue engineering and drug delivery.

Ansella Therapeutics utilizes its expertise in materials science and biomedical engineering to create unique, enhanced therapeutic approaches inspired by inherent anatomy, physiology, biochemistry, and endocrinology.

The company has launched its first product, Cerynë Intimate Care, for women with everyday vaginal dryness and designed for vulvovaginal application. Cerynë Intimate Care is the world’s first biomimetic formulation which works with your body to restore comfort and balance.

Cerynë Intimate care has been launched both directly to consumers and through physician channels as an intimate care product for vaginal dryness.

Ansella Therapeutics is developing a range of treatment that focus on Women’s Health including Menopause, Vaginal mucositis, Endometriosis, Uterine Fibroids and vaginal Infection.

Company overview

Avive Solutions is a MedTech company that has developed a next-generation automated external defibrillator (AED) and software solutions that revolutionizes the current sudden cardiac arrest (SCA) response. 

The device aims to significantly increase survival rates from SCA. 

The $3.5 billion global external defibrillators market is projected to have 9.7% compounded annual growth rate (CAGR) from 2024 to 2030. The AED market growth is  driven by legislation, property development and hospital groups, which has caused a shift in customer awareness and push for inbound sales models that the large players generally ignore in favor of entrenched distributor relationships.

The current SCA response system has a 10% survival rate, but when AEDs are used, the survival rate increases to over 40%.  The low AED usage is due to limited availability, improper maintenance, and a lack of connectivity in current AED machines. 

Avive’s automated external defibrillator (AED) device is a next-generation IoT (internet-of-things) device with complementary software solutions that has the ability to transform the existing flawed system for responding to Sudden Cardiac Arrest (SCA). Their system automates AED maintenance, tracks the AED, provides remote software updates, and automatically shares rescue data with emergency services, effectively eliminating the issues plaguing current aed machines. Their goal is to get an AED to a patient in under 4 minutes compared to the normal standard response time for emergency services which is 12 minutes. 

Company Overview

Caresyntax has developed an enterprise-grade surgical intelligence system that is vendor-neutral and equipped with proprietary software, hardware, and advanced AI capabilities. It can ingest and analyze data throughout the surgical workflow, including EMR, video, audio, image, device data, financial and outcomes data, and clinical and operational metrics to capture a complete picture of the surgical pathway. This allows the platform to generate insights across the entire continuum of care—before the procedure with surgical workflow optimization, during surgery with real-time clinically relevant support tools, and post procedure with clinical safety modules. The platform also produces data analytics and insights for medical device companies, insurers, and other ecosystem players to innovate and drive the future of healthcare delivery.
The Company has a footprint in 3,000 operating rooms, has been used in over 3 million surgeries, and has over 30,000 surgical users.

Company overview

Edeavors ENV-101 is a second-generation Hedgehog inhibitor with a highly favorable efficacy and side-effect profile compared to the molecules currently in the market. ENV-101 inhibits target pathway by ~90% at all tested doses.

Currently Hedgehog inhibitors are indicated for basal cell carcinoma. Significant data indicates the pathway involvement in fibrosis of the lungs. ENV-101 represents a significant improvement on existing therapies for IPF and is expected to be the Best-in-Class Hedgehog Inhibitor.

Attractive white space in the market
IPF market estimated to be $8.8B by 2027. SOC (standard of care), i.e., Boehringer Ingelheim’s Nintedanib (Ofev) has current sales >$3B with <20% market penetration based on prescription data. Current SOC has poor tolerability and efficacy.

Roche acquired InterMune in 2014 for $8.3 billion for Pirfenidone (Esbriet), indicated for IPF. Esbriet lost exclusivity in 2022 and Ofev is expected to lose exclusivity in 2025; which gives the next blockbuster significant white space for pricing and reimbursement. Both Ofev and Esbriet have severe and limiting GI issues for patients which ENV-101 seems to address.